“Our multi- chambered in vitro culture system provides a novel bioengineering solution that will enable the use of rodents to be reduced in neurodegeneration studies.”
Neurodegeneration is a component of many neurological disorders including multiple sclerosis, stroke and Alzheimer’s and Parkinson’s diseases. Understanding how to protect neurons from injury and death is a key area of research for new therapies. It is estimated worldwide that 130,000 rats and mice are used to study the cellular and molecular changes that occur during neurodegeneration.
NC3Rs-funded researchers, Professor Hugh Perry and Dr Tracey Newman, University of Southampton, have developed a microfluidic device that creates a suitable environment to study what happens during neuronal injury. This better understanding can inform how drugs are tested at the later stages of development, reducing the number of rodents that would be required.
Arundell M, Perry VH, Newman TA (2011). Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid-prototyping moulding process Lab on a Chip DOI: 10.1039/c1lc20120d